Author

J. W. Kelly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 3 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

L. Wiseman· 3 shared B. Rius· 2 shared I. C. Romine· 2 shared J. M. Grandjean· 2 shared R. J. Paxman· 2 shared R. L. Wiseman· 2 shared A. Madhavan· 1 shared B. Ganapathysubramanian· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

L. Wiseman

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease

C.-C. Chou, R. Vest, M. A. Prado, J. Wilson-Grady, J. A. Paulo, Y. Shibuya, P. Moran-Losada, T.-T. Lee, J. Luo, S. P. Gygi, J. W. Kelly, D. Finley, M. Wernig, T. Wyss-Coray, J. Frydman

This study uses transdifferentiated neurons to show lysosomal deficits are an early event in aging and Alzheimer's disease, leading to proteotoxic deposits and cell death.

bioRxiv · Mar 27, 2023Cell Biology

Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators

G. M. Kline, R. J. Paxman, C.-Y. Lin, N. Madrazo, J. M. Grandjean, K. Lee, K. Nugroho, E. Powers, L. Wiseman, J. W. Kelly

This study shows that AA132, a compound with a 2-amino-p-cresol substructure, globally activates all three UPR arms by covalently modifying ER PDIs, while AA147 selectively activates the ATF6 arm.

bioRxiv · Jan 16, 2023 · PreprintBiochemistry

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion Through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

J. S. Mezgarzadeh, I. C. Romine, E. M. Smith-Cohen, J. M. Grandjean, J. W. Kelly, J. C. Genereux, L. Wiseman

This study identifies how ATF6 activation reduces amyloidogenic TTR secretion through ER retention mediated by BiP and PDIA4, independent of redox activity.

bioRxiv · Apr 13, 2022Cell Biology

PERK Signaling Promotes Mitochondrial Elongation By Remodeling Membrane Phosphatidic Acid

V. Perea, C. Cole, J. Lebeau, V. Dolina, K. R. Baron, A. Madhavan, J. W. Kelly, D. Grotjahn, R. L. Wiseman

The paper shows PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid during ER stress.

bioRxiv · Feb 23, 2022Cell Biology

ER Proteostasis Regulators Reduce Amyloidogenic Light Chain Secretion Through an On-Target, ATF6-Independent Mechanism

B. Rius, J. S. Mesgarzadeh, I. C. Romine, R. J. Paxman, J. W. Kelly, L. Wiseman

This paper shows that compound 147 reduces amyloidogenic light chain secretion from AL patient plasma cells through PDI modification, independent of ATF6 activation.

bioRxiv · May 15, 2020 · PreprintBiochemistry

Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein

L. Plate, B. Rius, B. Nguyen, J. Genereux, J. W. Kelly, R. L. Wiseman

The paper identifies how ATF6 activation reduces secretion of a destabilized amyloidogenic protein by enhancing its retention in the ER through specific proteostasis factors.

bioRxiv · Jul 31, 2018Cell Biology

Crowdsourcing Image Analysis for Plant Phenomics to Generate Ground Truth Data for Machine Learning

N. Zhou, Z. D. Siegel, S. Zarecor, N. Lee, D. A. Campbell, C. M. Andorf, D. Nettleton, C. J. Lawrence-Dill, B. Ganapathysubramanian, J. W. Kelly, I. Friedberg

This paper evaluates crowdsourcing for generating high-quality ground truth data for machine learning in plant phenomics, finding that Amazon MTurk workers match expert performance.

bioRxiv · May 30, 2018Plant Biology

Translation efficiency is maintained at elevated temperature in E. coli

G. J. Morgan, D. H. Burkhardt, J. W. Kelly, E. T. Powers

The paper investigates how translation efficiency in E. coli remains stable under heat shock and finds that mRNA structure and cotranslational translocation influence this stability.

bioRxiv · Feb 16, 2017Biochemistry