Author

M. Pietrzak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Webb· 2 shared A. Amer· 1 shared A. Badr· 1 shared A. Eddy· 1 shared A. Forero· 1 shared A. Kenney· 1 shared A. Ludwig· 1 shared A. Quinones-Hinojosa· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

A. Webb

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis

M. Eltobgy, A. Zani, A. Kenney, S. Estfanous, E. Kim, A. Badr, C. Carafice, K. Daily, O. Whitham, M. Pietrzak, A. Webb, J. Kawahara, A. Eddy, P. Denz, M. Lu, , A. Amer

This study shows that caspase-4/11 worsens SARS-CoV-2 infection by increasing inflammation and thrombosis, independent of GSDMD, suggesting it as a potential drug target for severe COVID-19.

Proceedings of the National Academy of Sciences · May 19, 2022Peer-reviewedImmunology

Modeling of Aryl Hydrocarbon Receptor Pathway Intrinsic Immunometabolic Role using Glioblastoma Stem Cells and Patient-Derived Organoids

F. Watanabe, E. W. Hollingsworth, Y. Banasavadi-Siddegowda, J. M. Bartley, S. T. Sizemore, L. Yu, M. Pietrzak, P. Schiapparelli, V. Puduvalli, B. Kaur, A. Quinones-Hinojosa, J. Imitola

This study identifies AHR's role in regulating intrinsic immunity, proliferation, and migration in GBM stem cells and organoids, linking it to poor prognosis and suggesting it as a therapeutic target.

bioRxiv · Mar 17, 2022 · PreprintCancer Biology

Iron and lipocalin-2 modulate cellular responses in the tumor micro-environment of pancreatic ductal adenocarcinoma

V. Pita-Grisanti, A. W. Dangel, K. Gumpper, A. Ludwig, O. Ueltschi, X. M. Mo, M. Pietrzak, A. Webb, R. F. Hwang, M. Traczek, N. Badi, Z. Cruz-Monserrate

This study shows that iron and lipocalin-2 (LCN2) influence PDAC cell behavior and metastasis, with LCN2 deletion reducing metastasis and iron chelation increasing anti-metastatic gene expression.

bioRxiv · Jan 14, 2020 · PreprintCancer Biology