The Fc fragment of soluble IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement-dependent cytotoxicity
A. J. Pinto, A. Chouquet, I. Bally, V. Rossi, N. M. Thielens, C. Dumestre-Perard, R. Kunert, C. Gaboriaud, W. L. W. Ling, J.-B. REISER
This study investigates the binding of IgM Fc fragments to C1q and their role in complement activation and inhibition of cytotoxicity.
bioRxiv · Jul 10, 2024Biochemistry