I. Bally

The Fc fragment of soluble IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement-dependent cytotoxicity

This study investigates the binding of IgM Fc fragments to C1q and their role in complement activation and inhibition of cytotoxicity.

Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats

The paper identifies human antibodies targeting Plasmodium falciparum sexual stages, revealing cross-stage recognition of glutamate-rich repeats through a novel method.

Biophysical characterization of the oligomeric states of recombinant Immunoglobulins type-M and their C1q binding kinetics by Biolayer Interferometry

This study characterizes the oligomeric states and C1q binding kinetics of recombinant IgMs using biophysical methods, showing they retain complement activation function similar to plasma-derived IgMs.

Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization using a versatile adenovirus-inspired multimerization platform

This paper describes a vaccine platform using adenovirus-inspired nanoparticles decorated with SARS-CoV-2 RBD to elicit potent neutralizing antibodies in mice.

Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects Macaques from infection

This study develops a synthetic SARS-CoV-2 S glycoprotein virus-like particle vaccine that protects macaques from infection through strong antibody and T cell responses.

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

The paper shows DC/L-SIGN receptors on antigen-presenting cells enhance SARS-CoV-2 trans-infection, which can be blocked by a glycomimetic compound.