Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells
F. Petrelli, V. Scandella, S. Montessuit, N. Zamboni, J.-C. Martinou, M. Knobloch
This study shows that mitochondrial pyruvate carrier (MPC) regulates quiescent adult neural stem cells by linking glycolysis to mitochondrial metabolism, with MPC inhibition triggering NSPC activation and increased neurogenesis.
bioRxiv · May 31, 2022Cell Biology