N. Zamboni

GLUD1 dictates muscle stem cell differentiation by controlling mitochondrial glutamate levels

This study shows that GLUD1 controls muscle stem cell differentiation by regulating mitochondrial glutamate levels and the malate-aspartate shuttle.

Toxin-mediated depletion of nicotinamide dinucleotides drives persister formation in a human pathogen

This study shows that the RES domain TA system in P. aeruginosa promotes persister formation by depleting NAD and NADP under nutrient stress, enhancing bacterial survival during antibiotic treatment.

De novo serine biosynthesis is protective in mitochondrial disease

This study shows that de novo serine biosynthesis protects against mitochondrial disease by maintaining metabolic homeostasis, redox balance, and lipid homeostasis in skeletal muscle.

A non-canonical function of LDHB promotes SLC7A11-mediated glutathione metabolism and protects against glutaminolysis-dependent ferroptosis in KRAS-driven lung cancer

This study identifies a non-canonical role of LDHB in protecting KRAS-driven lung cancer from ferroptosis by promoting SLC7A11-mediated glutathione metabolism.

ROS induction as a strategy to target persister cancer cells with low metabolic activity in NRAS mutated melanoma

The paper identifies ROS induction as a strategy to target MEK-inhibitor resistant NRAS-mutated melanoma cells by exploiting their quiescent metabolic state and elevated baseline ROS levels.

Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells

This study shows that mitochondrial pyruvate carrier (MPC) regulates quiescent adult neural stem cells by linking glycolysis to mitochondrial metabolism, with MPC inhibition triggering NSPC activation and increased neurogenesis.

Structure of the connexin-43 gap junction channel in a putative closed state

The paper determines the structure of a human Cx43 gap junction channel in a closed state using cryo-EM, revealing a previously unknown conformation stabilized by a small molecule.

Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions

The paper identifies new peroxisomal functions in yeast by expanding the organellar proteome and analyzing sub-organellar localization and metabolic roles.

Spatial heterogeneity of glioblastoma cells reveals sensitivity to NAD+ depletion at tumor edge

This study identifies clonal subpopulations in glioblastoma core and edge lesions and shows that NAD+ depletion via CD38 inhibition reduces tumor edge formation.

Dynamic analysis of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs

This study dynamically analyzes sugar metabolism to uncover how synthetic sugar analogs are metabolized and their effects on cellular pathways.

Characterization of HIF-dependent alternative isoforms in pancreatic cancer

The paper identifies HIF-dependent alternative splicing events in pancreatic cancer cells under hypoxia and validates a novel long coding isoform of SLC35A3.