Cancer Cells in all EMT States Lack Rigidity Sensing Depletion of Different Tumor Suppressors Causes Loss of Rigidity Sensing in Cancer Cells
C. M. Simpson, V. Sundararajan, T. Z. Tan, R. Huang, M. Sheetz
The paper shows that cancer cells across different EMT states lack rigidity sensing, often due to missing tumor suppressors like Tpm2.1, and this loss contributes to their transformed phenotype.
bioRxiv · Jun 6, 2022 · PreprintCancer Biology