Bone marrow mesenchymal stromal cells mediate cellular inflammation in HFpEF
Kyle I. Mentkowski, I‐Hsiu Lee, David Rohde, Alexandre Paccalet, Hana Seung, Nina Kumowski, Maximilian J. Schloss, Michael Carpenito-Kronenfeld, Vaishali Kaushal, Ritika Jain, Xhoana Memcaj, Jacob E. Wiebe, Noor Momin, Steffen Pabel, Charlotte G. Muse, , Matthias Nahrendorf
The paper shows that bone marrow stromal cells in HFpEF respond to IFNγ, driving monocyte expansion and fibrosis, which can be mitigated by IFNγ receptor deletion.
bioRxiv · Mar 28, 2025 · PreprintImmunology