Author

Alexandre Paccalet

Harvard UniversityORCID 0000-0002-6331-562XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Charlotte G. MuseiD· 2 shared Hana SeungiD· 2 shared I‐Hsiu LeeiD· 2 shared Kamila NaxerovaiD· 2 shared Kyle I. MentkowskiiD· 2 shared Maarten HulsmansiD· 2 shared Matthias NahrendorfiD· 2 shared Maximilian J. SchlossiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Charlotte G. MuseORCID

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Author profile →

3 papers

Recent·Most cited

Therapeutic Spp1 silencing in TREM2+ cardiac macrophages suppresses atrial fibrillation

Noor Momin, Steffen Pabel, Arnab Rudra, Nina Kumowski, I‐Hsiu Lee, Hana Seung, Kyle I. Mentkowski, Aneesh C. Bapat, Masahiro Yamazoe, Laura Stengel, Charlotte G. Muse, Alexandre Paccalet, Farid F. Kadyrov, Cristina Gonzalez-Correa, Emily Jacobs, , Maarten Hulsmans

This study shows that silencing Spp1 in TREM2+ cardiac macrophages reduces atrial fibrosis and suppresses AFib in mice, suggesting a new immunotherapy approach.

Nature Cardiovascular Research · Apr 23, 2026Peer-reviewedImmunology

Bone marrow mesenchymal stromal cells mediate cellular inflammation in HFpEF

Kyle I. Mentkowski, I‐Hsiu Lee, David Rohde, Alexandre Paccalet, Hana Seung, Nina Kumowski, Maximilian J. Schloss, Michael Carpenito-Kronenfeld, Vaishali Kaushal, Ritika Jain, Xhoana Memcaj, Jacob E. Wiebe, Noor Momin, Steffen Pabel, Charlotte G. Muse, , Matthias Nahrendorf

The paper shows that bone marrow stromal cells in HFpEF respond to IFNγ, driving monocyte expansion and fibrosis, which can be mitigated by IFNγ receptor deletion.

bioRxiv · Mar 28, 2025 · PreprintImmunology

Brain virtual histology with X-ray phase-contrast tomography Part I: whole-brain myelin mapping in white-matter injury models

Matthieu Chourrout, Hugo Rositi, Elodie Ong, Violaine Hubert, Alexandre Paccalet, Louis Foucault, Awen Autret, Barbara Fayard C, Cécile Olivier, Radu I. Bolbos, Françoise Peyrin, Claire Crola Da Silva, David Meyronet, Olivier Raineteau, Hélène Elleaume, , Marlène Wiart

This paper introduces an X-ray phase-contrast tomography method to map myelin in whole rodent brains without staining, showing it can detect and quantify white-matter injuries in disease models.

Biomedical Optics Express · Nov 5, 2021Peer-reviewedNeuroscience