A protein-DNA surface hydrogel mechanically reinforces the cell nucleus and protects the genome
Ramesh Adakkattil, Pranay Mandal, Yahor Savich, Valentin Ruffine, Mareike A. Jordan, Henrik Dahl Pinholt, Elisabeth Fischer‐Friedrich, Frank Jülicher, Stephan W. Grill, Alexander von Appen
The paper shows a protein-DNA co-condensate forms a surface hydrogel that mechanically reinforces the nucleus and protects DNA from damage during mechanical stress.
bioRxiv · May 21, 2025 · PreprintBiophysics