Alexander von Appen

The paper elucidates the structural mechanism of nuclear membrane sealing by LEM2-ESCRT-III through a combination of biochemical and structural methods.

The paper identifies lipid specificity in membrane organizing protein complexes by mapping lipid-protein interactions and demonstrating phosphatidylethanolamine's role in stabilizing NDC1 and MIC60.

This study shows that increased somatodendritic Tau interacts with nuclear envelope proteins, causing nuclear damage and altering gene expression related to AD and tauopathies.

The paper shows a protein-DNA co-condensate forms a surface hydrogel that mechanically reinforces the nucleus and protects DNA from damage during mechanical stress.

This study determines the high-resolution structure of the ciliary glycocalyx in Chlamydomonas reinhardtii and identifies FMG1B as a mucin-like protein with unique glycosylation features.

This study shows that a minimal cell membrane with two lipid species can support life, highlighting the importance of acyl chain diversity over head group diversity.