Circular mRNA against Clean Cap linear mRNA vectors comprehensive comparison, expression, active and passive immunization
Vladimir M. Vakhtinskii, Тутыхина Ирина Леонидовна, Alina Sh. Dzharullaeva, Daria M. Grousova, Ilya D. Zorkov, Anna A. Iliukhina, D. A. Reshetnikov, Valentin V. Azizyan, Artem A. Derkaev, Evgeniia N. Bykonia, Evgeny V. Usachev, Denis A. Kleymenov, Vladimir А. Gushchin, Inna V. Dolzhikova, Dmitry V. Shcheblyakov, , Gintsburg Al
This study compares circular and linear mRNA vectors, finding linear vectors have higher expression levels but equal immunogenicity and protective activity.
Frontiers in Immunology · Apr 24, 2026Peer-reviewedImmunology