Vladimir А. Gushchin

Circular mRNA against Clean Cap linear mRNA vectors comprehensive comparison, expression, active and passive immunization

This study compares circular and linear mRNA vectors, finding linear vectors have higher expression levels but equal immunogenicity and protective activity.

Oral Administration of the carboxylic acid ester prodrug NHC SN_9 protects mice from lethal Orthopoxvirus challenge: Implications for the Treatment of Monkeypox

This study evaluates the antiviral efficacy of SN_9, a prodrug of NHC, against orthopoxviruses in mice, showing significant survival and reduced disease severity.

Characterization of a lethal Crimean-Congo hemorrhagic fever virus infection model in interferon-deficient mice for studies of virus pathogenicity and vaccine efficacy

This study establishes an IFN-deficient mouse model for CCHFV infection to evaluate pathogenicity and vaccine efficacy.

Comparison candidate Tick-borne encephalitis virus vaccines based on mRNA, adenovirus serotype 25 and chimera of YFV vaccine strain

This study compares three TBEV vaccine candidates—mRNA-LNP, recombinant adenovirus, and YFV chimera—and finds the mRNA-LNP vaccine has higher immunogenicity and protective efficacy in mice.

Single-domain antibody delivery using an mRNA platform protects against lethal doses of botulinum neurotoxin A

This paper develops an mRNA platform for delivering single-domain antibodies, achieving 100% protection against high doses of botulinum neurotoxin A in mice.

First isolation and characterisation of Alongshan virus in Russia

The paper isolates and characterizes three strains of Alongshan virus from Russian ticks, identifies novel genomic features, and confirms the utility of tick cell lines for virus maintenance.