Brainstem cholinergic cell loss causes slowly-developing motor impairments
Kenea C Udobi, Valeria Aleman, Valerie J. Lewitus, Michel Fallah, Briana J. Bernstein, Grace Zhang, Miguel Ezeiza Ortega, Christian Konja, Sarah Grossen, Patrick Alexander Forcelli, Nathan D. Neckel, Rebekah C. Evans
This study develops a mouse model of brainstem cholinergic cell loss to show delayed motor impairments and circuit reorganization in Parkinson's disease.
bioRxiv · Oct 17, 2026 · PreprintNeuroscience