The Anaphase Promoting Complex targets the toxic protein Progerin for ubiquitin-dependent degradation via autophagy
Valeria Martinez, Matthew Lubachowski, Zoe E. Gillespie, Morgan Fleming, Troy A. A. Harkness, Christopher H. Eskiw
This study identifies the Anaphase Promoting Complex (APC) as a mediator of progerin degradation via autophagy in Hutchinson-Gilford Progeria Syndrome.
bioRxiv · Jul 24, 2026 · PreprintCell Biology