Myofibroblast- specific autophagy drives cyst growth in autosomal dominant polycystic kidney disease
Abeda Jamadar, Viji Remadevi, Meekha M. Varghese, Haichun Yang, Vedant P. Thakkar, Indra Chandrasekar, Wen‐Xing Ding, Volker H. Haase, Darren P. Wallace, Reena Rao
This study shows that autophagy in myofibroblasts drives cyst growth in ADPKD by promoting paracrine stimulation of epithelial cells, with lactate and HIF1 playing key roles.
Cell Communication and Signaling · Jul 9, 2026Peer-reviewedMolecular Biology