Wen‐Xing Ding

Myofibroblast- specific autophagy drives cyst growth in autosomal dominant polycystic kidney disease

This study shows that autophagy in myofibroblasts drives cyst growth in ADPKD by promoting paracrine stimulation of epithelial cells, with lactate and HIF1 playing key roles.

Aging promotes inflammation and steatosis in alcohol-associated liver disease in mice

This study shows that aging worsens alcohol-induced liver damage in mice by increasing inflammation and fat accumulation, and suggests targeting TFEB could help.

Overlapping yet Distinct Functions of VMP1 and TMEM41B in Modulating Hepatic Lipoprotein Secretion and Autophagy

This study investigates the distinct roles of VMP1 and TMEM41B in hepatic lipoprotein secretion and autophagy, showing that VMP1 has a more critical role in regulating these processes in MASLD.

Disruption of Mitochondrial Dynamics and Stasis Leads to Liver Injury and Tumorigenesis

This study shows that disrupting mitochondrial fission (DRP1) leads to liver injury and tumorigenesis, while loss of fusion proteins has less impact, and triple knockout mice show reduced tumor development.