Haichun Yang

This study shows pirfenidone reduces fibrosis and improves kidney function in ADPKD by targeting myofibroblast activation and ECM production.

This study shows that autophagy in myofibroblasts drives cyst growth in ADPKD by promoting paracrine stimulation of epithelial cells, with lactate and HIF1 playing key roles.

The paper introduces a method to uncover molecular substructures in human kidney tissue using signal strength-aware latent spaces, revealing previously unknown lipid species and biological subdivisions.

This paper surveys computer vision methods for spatial transcriptomics, categorizing models and discussing challenges and future directions.

The paper shows that partial repair after urinary obstruction reversal causes permanent structural and functional defects in the renal papilla in mice.

This paper integrates MALDI IMS and MxIF microscopy to analyze lipid and molecular profiles of glomerular cell types and substructures in human kidney tissue.