Bone marrow stromal cells induce an ALDH+ stem cell-like phenotype in AML cells through TGF-β-p38-ALDH2 pathway
Bin Yuan, Fouad El Dana, Stanley Ly, Yuanqing Yan, Vivian Ruvolo, Elizabeth J. Shpall, Marina Konopleva, Michael Andreeff, Venkata Lokesh Battula
This study identifies the TGF-β-p38-ALDH2 pathway as a mechanism by which bone marrow stromal cells induce an ALDH+ stem cell-like phenotype in AML cells, promoting chemotherapy resistance.
bioRxiv · Jul 10, 2020Cancer Biology