Melatonin nanoparticles inhibit mutant hematopoiesis and restore bone marrow architecture in myeloproliferative neoplasms
Siddharth Gupta, Alessandro Motta, Sara Elsafy, Shiva Khorshid, Alessia Nucci, Vishrutha Sampath, Ananya Bhattacharjee, Margherita Vieri, Kathrin Olschok, Kristina Pannen, Jelena Lazarevic, Maria Jimena Rodriguez, Patrick Weiand, Venkatakrishnan Hariharan, Cristina Baquero López, , Nicolas Chatain
This study shows that melatonin nanoparticles reduce myeloproliferative neoplasm symptoms by targeting metabolic, inflammatory, and fibrotic pathways.
bioRxiv · Aug 31, 2026 · PreprintCancer Biology