Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at the Xist locus
Rutger A. F. Gjaltema, Till Schwämmle, Pauline Kautz, Michael I. Robson, Robert Schöpflin, Liat Ravid Lustig, Lennart Brandenburg, Ilona Dunkel, Carolina Vechiatto, Evgenia Ntini, Verena Mutzel, Vera Schmiedel, Annalisa Marsico, Stefan Mundlos, Edda G. Schulz
The paper identifies distal and proximal cis-regulatory elements that respond to X-chromosomal dosage and developmental state to regulate Xist expression during XCI in mouse embryonic stem cells.
Molecular Cell · Dec 20, 2021Peer-reviewedGenomics