Author

Pauline Kautz

Max Delbrück CenterORCID 0000-0002-9658-1676Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Leif S. LudwigiD· 3 shared Ansuman T. SatpathyiD· 2 shared Caleb A. LareauiD· 2 shared Lena NitschiD· 2 shared Agostina BianchiiD· 1 shared Alejo Rodriguez-FraticelliiD· 1 shared Annalisa MarsicoiD· 1 shared Anshul Bharat KundajeiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersGenomics

Leif S. LudwigORCID

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Author profile →

4 papers

Recent·Most cited

Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan

Michael Scherer, Indranil Singh, Martina Maria Braun, Chelsea Szu‐Tu, Pedro Sánchez-Sánchez, Dominik Lindenhofer, Niels Asger Jakobsen, Verena Körber, Michael Kardorff, Lena Nitsch, Pauline Kautz, Julia Rühle, Agostina Bianchi, Luca Cozzuto, Robert Frömel, , Lars Velten

This paper introduces EPI-clone, a method using DNA methylation to trace clonal lineages in hematopoiesis without genetic engineering, showing clonal complexity declines with age in mice and expands in humans.

Nature · May 21, 2025Peer-reviewedGenomics

Tissue-specific apparent mtDNA heteroplasmy and its relationship with ageing and mtDNA gene expression

Simon Wengert, Xenofon Giannoulis, Peter Kreitmaier, Pauline Kautz, Leif S. Ludwig, Holger Prokisch, Francesco Paolo Casale, Matthias Heinig, Na Cai

The paper maps tissue-specific mtDNA heteroplasmy and its associations with age and mtDNA gene expression using bulk RNAseq data from GTEx.

bioRxiv · Dec 11, 2024 · PreprintGenomics

Single-cell multi-omics reveals dynamics of purifying selection of pathogenic mitochondrial DNA across human immune cells

Caleb A. Lareau, Sonia M. Dubois, Frank A. Buquicchio, Yu-Hsin Hsieh, Kopal Garg, Pauline Kautz, Lena Nitsch, Samantha D. Praktiknjo, Patrick Maschmeyer, Jeffrey M. Verboon, Jacob C. Gutierrez, Yajie Yin, Evgenij Fiškin, Wendy Luo, Eleni P. Mimitou, , Leif S. Ludwig

The paper uses single-cell multi-omics to study how pathogenic mtDNA mutations are subject to purifying selection in immune cells from Pearson syndrome patients.

bioRxiv · Nov 20, 2022 · PreprintGenetics

Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at the Xist locus

Rutger A. F. Gjaltema, Till Schwämmle, Pauline Kautz, Michael I. Robson, Robert Schöpflin, Liat Ravid Lustig, Lennart Brandenburg, Ilona Dunkel, Carolina Vechiatto, Evgenia Ntini, Verena Mutzel, Vera Schmiedel, Annalisa Marsico, Stefan Mundlos, Edda G. Schulz

The paper identifies distal and proximal cis-regulatory elements that respond to X-chromosomal dosage and developmental state to regulate Xist expression during XCI in mouse embryonic stem cells.

Molecular Cell · Dec 20, 2021Peer-reviewedGenomics