Resolving symmetry-masked allosteric cooperativity in the M. tuberculosis proteasome core particle
Madison Turner, Verena Wittlinger, Cristina Lento, Anisha Haris, Jakub Ujma, David Bruton, Keith Richardson, Kevin Giles, Thomas Böttcher, Derek Wilson, Siavash Vahidi
This paper demonstrates positive cooperativity between subunits in the M. tuberculosis 20S proteasome core particle by using a hybrid subunit assembly and isotopic-coding strategy to resolve symmetry-masked allostery.
bioRxiv · Jul 3, 2026 · PreprintBiochemistry