Kevin Giles

This study uses cryo-EM and charge detection mass spectrometry to determine the stoichiometry and structure of Bpa-substrate complexes in Mtb, revealing an undecameric apo form and a Bpa12:HspR2 complex.

This paper demonstrates positive cooperativity between subunits in the M. tuberculosis 20S proteasome core particle by using a hybrid subunit assembly and isotopic-coding strategy to resolve symmetry-masked allostery.

This paper describes the design of a benchtop ELIT-based CDMS instrument and presents its performance metrics for analyzing high-molecular-weight species.

This study compares two CDMS methods to analyze norovirus capsid assembly, revealing non-classical mass distributions in GII.17 Kawasaki capsids confirmed by cryo-EM.

This study defines the temperature-sensitive oligomerization mechanism of Bpa and elucidates its interaction with a surrogate substrate using biophysical techniques.