Author

David Bruton

Waters (United Kingdom)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:human· 1

Frequent Co-Authors

Anisha HarisiD· 4 shared Jakub UjmaiD· 4 shared Keith RichardsoniD· 4 shared Kevin GilesiD· 4 shared Siavash VahidiiD· 3 shared Bradley T. V. DavisiD· 2 shared Adwaith B. UdayiD· 1 shared Alexander F. A. KeszeiiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersBiochemistry

Anisha HarisORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Resolving hidden stoichiometries in Bacterial proteasome activator (Bpa)-substrate complexes by cryo-EM and charge detection mass spectrometry

Bradley T. V. Davis, Adwaith B. Uday, Anisha Haris, Alexander F. A. Keszei, Jakub Ujma, David Bruton, Keith Richardson, Mohammad T. Mazhab‐Jafari, Kevin Giles, Natalie Zeytuni, Siavash Vahidi

This study uses cryo-EM and charge detection mass spectrometry to determine the stoichiometry and structure of Bpa-substrate complexes in Mtb, revealing an undecameric apo form and a Bpa12:HspR2 complex.

Journal of the American Chemical Society · Aug 14, 2026Peer-reviewedBiochemistry

Resolving symmetry-masked allosteric cooperativity in the M. tuberculosis proteasome core particle

Madison Turner, Verena Wittlinger, Cristina Lento, Anisha Haris, Jakub Ujma, David Bruton, Keith Richardson, Kevin Giles, Thomas Böttcher, Derek Wilson, Siavash Vahidi

This paper demonstrates positive cooperativity between subunits in the M. tuberculosis 20S proteasome core particle by using a hybrid subunit assembly and isotopic-coding strategy to resolve symmetry-masked allostery.

bioRxiv · Jul 3, 2026 · PreprintBiochemistry

A Charge Detection Mass Spectrometer for the Analysis of Megadalton-sized Molecules

Jakub Ujma, Chris Wheeldon, Alistair Schofield, Michael Danby, David Eatough, David Bruton, Anisha Haris, Keith Richardson, David Langridge, Andy Jarrell, Jeffery Mark Brown, Benjamin E. Draper, Martin F. Jarrold, Kevin Giles

This paper describes the design of a benchtop ELIT-based CDMS instrument and presents its performance metrics for analyzing high-molecular-weight species.

bioRxiv · Jun 10, 2026 · PreprintBiophysics

Assembly and substrate engagement mechanism of the bacterial proteasome activator Boa

Bradley T. V. Davis, Enrico Rennella, Anisha Haris, Jakub Ujma, David Bruton, Keith Richardson, Kevin Giles, Lewis E. Kay, Siavash Vahidi

This study defines the temperature-sensitive oligomerization mechanism of Bpa and elucidates its interaction with a surrogate substrate using biophysical techniques.

bioRxiv · Oct 1, 2025 · PreprintBiochemistry