Cristina Lento

This paper demonstrates positive cooperativity between subunits in the M. tuberculosis 20S proteasome core particle by using a hybrid subunit assembly and isotopic-coding strategy to resolve symmetry-masked allostery.

This paper shows that the antibody ICO-hu104 neutralizes SARS-CoV-2 by causing allosteric changes in the HR1 domain, leading to destabilization of helices and impairing viral fusion.

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

This study uses hydrogen deuterium exchange mass spectrometry to show that Mcl-1's binding specificity arises from dynamic modes in its unbound state, distinct from Bcl-2.