GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging
In Hwa Jang, Anna Carey, Victor Kruglov, Katie Nguyen, Jeffrey R. Misialek, Stephanie H. Cholensky, Declan M. Smith, Suxia Bai, Timothy Nottoli, David Bernlohr, Pamela L. Lutsey, Christina D. Camell
This study shows that GDF3 promotes inflammation in aged adipose tissue macrophages via SMAD2/3 signaling and chromatin changes, offering a therapeutic target for age-related inflammation.
Nature Aging · Dec 15, 2025Peer-reviewedImmunology