ScreenDMT identifies metabolites consistently linked to sleep disorders across three human cohorts, revealing replicable associations with insomnia, sleep duration, and daytime sleepiness.

bioRxiv · Oct 13, 2026 · PreprintBioinformatics

GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging

In Hwa Jang, Anna Carey, Victor Kruglov, Katie Nguyen, Jeffrey R. Misialek, Stephanie H. Cholensky, Declan M. Smith, Suxia Bai, Timothy Nottoli, David Bernlohr, Pamela L. Lutsey, Christina D. Camell

This study shows that GDF3 promotes inflammation in aged adipose tissue macrophages via SMAD2/3 signaling and chromatin changes, offering a therapeutic target for age-related inflammation.

Nature Aging · Dec 15, 2025Peer-reviewedImmunology

Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors

Florian Thibord, Derek M. Klarin, Jennifer A. Brody, Ming‐Huei Chen, Michael G. Levin, Daniel I. Chasman, Ellen L. Goode, Kristian Hveem, Maris Teder‐Laving, Ángel Martínez-Pérez, Dylan Aïssi, Delphine Daian-Bacq, Kaoru Ito, Pradeep Natarajan, Pamela L. Lutsey, , Nicholas L. Smith

This study identifies 135 genomic loci associated with venous thromboembolism risk through cross-ancestry GWAS and provides insights into biological pathways and potential therapeutic targets.

Circulation · Oct 17, 2022Peer-reviewedGenetic & Genomic Medicine