NeurosciencebioRxivPreprint
Rules of disengagement: orexin-arousal and dopamine-utility as separable axes
Nikola Grujic, Victoria Isabella Ploerer, Mattia Hamann…·Denis Burdakov
The paper identifies two separable neurochemical axes—orexin-driven arousal and dopamine-mediated utility—that govern task engagement in mice, with implications for drug effects and motivation disorders.
DOI 10.64898/2026.10.25.761642