Author

Vignesh Senguttuvan

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:variant effect prediction· 2 Research Focus:imputation· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Frederick P. RothiD· 3 shared Warren van LoggerenbergiD· 3 shared Alexander Wahl· 2 shared Alireza RasoulzadehiD· 2 shared Anna AxakovaiD· 2 shared Haotian ZhangiD· 2 shared Marinella GebbiaiD· 2 shared Adele A. Mitchell· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersGenetics

Frederick P. RothORCID

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3 papers

Recent·Most cited

Inferring Protein Variant Impacts Across Contexts

Alireza Rasoulzadeh, Vignesh Senguttuvan, Warren van Loggerenberg, Richard Border, Frederick P. Roth

The paper evaluates imputation methods for contextual variant effects in MAVE studies, finding that method choice depends on data density and task requirements.

bioRxiv · Aug 20, 2026 · PreprintGenetics

Environment-dependent landscapes of coding variant impacts on coproporphyrinogen oxidase

Warren van Loggerenberg, Haotian Zhang, Vignesh Senguttuvan, Michael James Chambers, Mailoan Panchalingam, Alireza Rasoulzadeh, Anna Axakova, Marinella Gebbia, Robert J. Desnick, Bruce Wang, Caroline Schmitt, Laurent Gouya, Jordi To‐Figueras, Alexander Wahl, İvet Bahar, , Frederick P. Roth

The paper systematically assesses the functional impact of CPOX variants under different environmental conditions, revealing mercury-dependent variant effects and improving variant classification.

bioRxiv · Jul 3, 2026 · PreprintMolecular Biology

Landscapes of missense variant impact for human superoxide dismutase 1

Anna Axakova, M. Ding, Atina G. Coté, Radha Subramaniam, Vignesh Senguttuvan, Haotian Zhang, Jochen Weile, Samuel V. Douville, Marinella Gebbia, Ammar Al‐Chalabi, Alexander Wahl, Jason Reuter, Jessica A. Hurt, Adele A. Mitchell, Stephanie Fradette, , Frederick P. Roth

The paper measures the functional impact of over two thousand SOD1 missense variants using saturation mutagenesis and cell-based assays, reclassifying 41% of previously uncertain variants as pathogenic.

The American Journal of Human Genetics · Sep 16, 2025Peer-reviewedGenetics