Author

Haotian Zhang

University of PittsburghORCID 0000-0002-1461-0200Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Haotian Zhang1 paper · The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:variant effect prediction· 2 Assay:proteomics· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Alexander Wahl· 2 shared Anna AxakovaiD· 2 shared Frederick P. RothiD· 2 shared Marinella GebbiaiD· 2 shared Vignesh Senguttuvan· 2 shared Warren van LoggerenbergiD· 2 shared Adele A. Mitchell· 1 shared Alireza RasoulzadehiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersMolecular Biology

Alexander Wahl

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2 papers

Recent·Most cited

Environment-dependent landscapes of coding variant impacts on coproporphyrinogen oxidase

Warren van Loggerenberg, Haotian Zhang, Vignesh Senguttuvan, Michael James Chambers, Mailoan Panchalingam, Alireza Rasoulzadeh, Anna Axakova, Marinella Gebbia, Robert J. Desnick, Bruce Wang, Caroline Schmitt, Laurent Gouya, Jordi To‐Figueras, Alexander Wahl, İvet Bahar, , Frederick P. Roth

The paper systematically assesses the functional impact of CPOX variants under different environmental conditions, revealing mercury-dependent variant effects and improving variant classification.

bioRxiv · Jul 3, 2026 · PreprintMolecular Biology

Landscapes of missense variant impact for human superoxide dismutase 1

Anna Axakova, M. Ding, Atina G. Coté, Radha Subramaniam, Vignesh Senguttuvan, Haotian Zhang, Jochen Weile, Samuel V. Douville, Marinella Gebbia, Ammar Al‐Chalabi, Alexander Wahl, Jason Reuter, Jessica A. Hurt, Adele A. Mitchell, Stephanie Fradette, , Frederick P. Roth

The paper measures the functional impact of over two thousand SOD1 missense variants using saturation mutagenesis and cell-based assays, reclassifying 41% of previously uncertain variants as pathogenic.

The American Journal of Human Genetics · Sep 16, 2025Peer-reviewedGenetics