Michael James Chambers

High-throughput Eukaryotic Screening of Putative Anti-CRISPR Proteins against SpyCas9 and SauCas9

The paper screens hundreds of anti-CRISPR homologs to inhibit SpyCas9 and SauCas9, revealing evolutionary patterns and discovering three novel Acr families.

Systematic screen of PKR reveals genetic variants that broadly evade divergent viral pseudosubstrate inhibitors

This study screens genetic variants of PKR to identify those that resist diverse viral pseudosubstrate inhibitors, finding shared resistance mechanisms across different inhibitors.

Environment-dependent landscapes of coding variant impacts on coproporphyrinogen oxidase

The paper systematically assesses the functional impact of CPOX variants under different environmental conditions, revealing mercury-dependent variant effects and improving variant classification.

Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic

This study identifies K3-resistant variants in the PKR kinase domain and shows their enrichment under positive selection and resilience to viral adaptation.

Systematic characterization of the local evolutionary space available to human PKR and vaccinia virus K3

The paper systematically explores genetic variants in human PKR and vaccinia virus K3 to understand their evolutionary dynamics and functional interactions.

Long-read genomes reveal pangenomic variation underlying yeast phenotypic diversity

The paper uses long-read sequencing to identify pangenomic genes contributing to yeast phenotypic variation by resolving QTLs that are missed by short-read methods.