Bruce Wang

The paper integrates multiple datasets to create a comprehensive human liver cell atlas, identifying new cell types and associations with demographic factors.

The paper systematically assesses the functional impact of CPOX variants under different environmental conditions, revealing mercury-dependent variant effects and improving variant classification.

This study identifies PCSK9 as a key determinant of metastatic organ preference in pancreatic cancer by regulating cholesterol acquisition and utilization in liver versus lung environments.

This study shows that perinatal liver inflammation leads to long-term changes in myeloid progenitors through the CXCL10-CXCR3 axis, which may contribute to immune dysfunction in biliary atresia.

The paper characterizes the transcriptional response to COVID-19 across multiple organs using single-nuclei RNA sequencing, identifying shared transcriptional signatures in endothelial cells and macrophages.

The paper compares MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing in mouse liver and kidney, finding MERFISH provides comparable results and robust cell type identification without needing integration with scRNA-seq atlases.

This paper introduces scDRS, a method to identify disease-associated cells in scRNA-seq data using polygenic risk scores, finding novel subpopulations linked to diseases like IBD and schizophrenia.

The paper shows that pituitary stem cells secrete WNT signals that promote the proliferation of neighboring progenitor cells.

This study shows that Wnt/β-catenin signaling, driven by endothelial cells, is critical for liver repair after acute carbon tetrachloride injury.