Low Affinity Binding Sites in an Activating CRM Mediate Negative Autoregulation of the Drosophila Hox Gene Ultrabithorax
Rebecca K. Delker, Vikram Ranade, Ryan Loker, Roumen Voutev, Richard S. Mann
The paper identifies a negative autoregulatory loop mediated by low-affinity Ubx-Exd binding sites in the Drosophila Hox gene Ultrabithorax, maintaining differential expression levels in distinct compartments.
PLoS Genetics · Oct 7, 2019Peer-reviewedDevelopmental Biology