Ryan Loker

The paper shows that a long non-coding RNA, Gul, coordinates GABAergic gene expression by interacting with 3'UTR sites of target mRNAs in Drosophila neurons.

The paper shows Hox paralogs use different cofactors in distinct domains to activate specific gene regulatory networks in Drosophila legs.

The paper shows Ubx, a Hox protein, alters chromatin accessibility in both directions, affecting gene regulation and tissue identity in Drosophila.

The paper identifies a negative autoregulatory loop mediated by low-affinity Ubx-Exd binding sites in the Drosophila Hox gene Ultrabithorax, maintaining differential expression levels in distinct compartments.

The paper investigates how DNA sequence influences the formation of transcription factor complexes and shows that non-canonical binding sites arise from direct interactions with functionally bound sites.