Dark selection for JAK/STAT-inhibitor resistance in chronic myelomonocytic leukemia
Artem Kaznatcheev, David Robert Grimes, Robert Vander Velde, Vincent Cannataro, Etienne Baratchart, Andrew Dhawan, Lin Liu, Daria Myroshnychenko, Jake P. Taylor-King, Nara Yoon, Eric Padron, Andriy Marusyk, David Basanta
The paper challenges the classic U-shape model of resistance by proposing alternative population-level models for ruxolitinib resistance in CMML and explores the role of oxygen and cytokine signaling in resistance dynamics.
bioRxiv · Oct 30, 2017 · PreprintCancer Biology