Author

Artem Kaznatcheev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Evolutionary Biology· 1

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Approach:statistical model· 4 Approach:deep learning· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

David BasantaiD· 3 shared David Robert Grimes· 2 shared Jacob G Scott· 2 shared Jake P. Taylor-King· 2 shared Robert Vander VeldeiD· 2 shared Andrew DhawaniD· 1 shared Andriy MarusykiD· 1 shared Arturo Araujo· 1 shared

Activity by Year

2015-2017 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCancer Biology

David BasantaORCID

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Author profile →

5 papers

Recent·Most cited

Two conceptions of evolutionary games: reductive vs effective

Artem Kaznatcheev

This paper distinguishes between reductive and effective games in evolutionary game theory based on differing interpretations of fitness, highlighting implications for theoretical and experimental work.

bioRxiv · Dec 11, 2017 · PreprintEvolutionary Biology

Dark selection for JAK/STAT-inhibitor resistance in chronic myelomonocytic leukemia

Artem Kaznatcheev, David Robert Grimes, Robert Vander Velde, Vincent Cannataro, Etienne Baratchart, Andrew Dhawan, Lin Liu, Daria Myroshnychenko, Jake P. Taylor-King, Nara Yoon, Eric Padron, Andriy Marusyk, David Basanta

The paper challenges the classic U-shape model of resistance by proposing alternative population-level models for ruxolitinib resistance in CMML and explores the role of oxygen and cytokine signaling in resistance dynamics.

bioRxiv · Oct 30, 2017 · PreprintCancer Biology

Cancer treatment scheduling and dynamic heterogeneity in social dilemmas of tumour acidity and vasculature

Artem Kaznatcheev, Robert Vander Velde, Jacob G Scott, David Basanta

This paper uses evolutionary game theory to model tumour heterogeneity in glycolysis, angiogenesis, and oxygen availability, showing dynamic regimes and the importance of treatment timing.

bioRxiv · Aug 2, 2016Cancer Biology

Toxicity Management in CAR T cell therapy for B-ALL: Mathematical modelling as a new avenue for improvement.

Shalla Hanson, David Robert Grimes, Jake P. Taylor-King, Benedikt Bauer, Pravnam I. Warman, Ziv Frankenstein, Artem Kaznatcheev, Michael J. Bonassar, Vincent L. Cannataro, Zeinab Y. Motawe, Ernesto A. B. F. Lima, Sungjune Kim, Marco L. Davila, Arturo Araujo

This paper develops a mathematical model to explore toxicity in CAR T cell therapy for B-ALL, finding that initial tumour burden is a stronger predictor of toxicity than CAR T cell dose.

bioRxiv · Apr 22, 2016 · PreprintCancer Biology

Edge effects in game theoretic dynamics of spatially structured tumours

Artem Kaznatcheev, Jacob G Scott, David Basanta

This paper shows spatial structure in tumor models can promote invasive cell strategies at tumor edges, using a game-theoretic approach to analyze metastatic potential.

bioRxiv · Jan 23, 2015Cancer Biology