Author

David Robert Grimes

Primary ORCID profile (0000-0003-3140-3278 · 3 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

David Robert GrimesiD3 papers · Cancer Research UK

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:human· 3 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Artem Kaznatcheev· 2 shared Jake P. Taylor-King· 2 shared Abul Siddiky· 1 shared Adrian Harris· 1 shared Alan McIntyreiD· 1 shared Andrew DhawaniD· 1 shared Andriy MarusykiD· 1 shared Anthony Kavanagh· 1 shared

Activity by Year

2016-2017 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

Artem Kaznatcheev

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Author profile →

3 papers

Recent·Most cited

Dark selection for JAK/STAT-inhibitor resistance in chronic myelomonocytic leukemia

Artem Kaznatcheev, David Robert Grimes, Robert Vander Velde, Vincent Cannataro, Etienne Baratchart, Andrew Dhawan, Lin Liu, Daria Myroshnychenko, Jake P. Taylor-King, Nara Yoon, Eric Padron, Andriy Marusyk, David Basanta

The paper challenges the classic U-shape model of resistance by proposing alternative population-level models for ruxolitinib resistance in CMML and explores the role of oxygen and cytokine signaling in resistance dynamics.

bioRxiv · Oct 30, 2017 · PreprintCancer Biology

Toxicity Management in CAR T cell therapy for B-ALL: Mathematical modelling as a new avenue for improvement.

Shalla Hanson, David Robert Grimes, Jake P. Taylor-King, Benedikt Bauer, Pravnam I. Warman, Ziv Frankenstein, Artem Kaznatcheev, Michael J. Bonassar, Vincent L. Cannataro, Zeinab Y. Motawe, Ernesto A. B. F. Lima, Sungjune Kim, Marco L. Davila, Arturo Araujo

This paper develops a mathematical model to explore toxicity in CAR T cell therapy for B-ALL, finding that initial tumour burden is a stronger predictor of toxicity than CAR T cell dose.

bioRxiv · Apr 22, 2016 · PreprintCancer Biology

The role of oxygen in avascular tumor growth

David Robert Grimes, Pavitra Kannan, Alan McIntyre, Anthony Kavanagh, Abul Siddiky, Simon Wigfield, Adrian Harris, Mike Partridge

This study examines oxygen dynamics in tumor spheroids, showing that growth can be mechanistically modeled using cellular doubling time and oxygen consumption rate, validated with clinical measurements and treatment response.

PLOS ONE · Apr 18, 2016Peer-reviewedCancer Biology