Vincent J. Lynch

This study shows that CGAS and STING1 genes are pseudogenized in armadillos, suggesting alternative mechanisms for sensing dsDNA and possibly contributing to their cancer resistance.

The paper identifies gene losses in regulated necrotic cell death pathways in elephants, hyraxes, and sea cows, linking these losses to traits like large body size and cancer resistance.

The paper identifies positively selected and rapidly evolving genes in elephants that may contribute to their cancer resistance.

This study uses phylogenomic data to analyze the branching order of Paenungulata, finding strong evidence for a polytomy with limited gene support for any specific resolution.

The paper integrates GWAS data with functional genomic annotations of decidual stromal cells to identify loci and target genes associated with gestational duration and preterm birth.

This study identifies deleterious mutations in Wrangel Island mammoths and shows their potential functional impacts on development, fertility, and sensory abilities.

This study establishes endometrial gland organoids from term placental decidua and identifies survival factors for co-culture with stromal fibroblasts, enabling patient-specific models with known pregnancy outcomes.

The paper identifies a G/A polymorphism in rs2523393 that creates a new GATA2 binding site in an HLA-F enhancer, associated with fecundability and linked to multiple sclerosis risk.

This study identifies mammoth-specific TRPM8 mutations that confer thermal desensitization while preserving sensitivity to chemical coolants.

The paper identifies transposable elements as the main source of novelty in primate gene regulation by analyzing conserved and newly evolved cis-regulatory elements across six primate species.

The paper identifies a polymorphism in TAP2 that functions as a repressor or enhancer depending on allele, with evolutionary and functional implications for fecundability and immune-related diseases.