Spatiotemporal dynamics of adoptively transferred stem-like CD8+ T cells in the tumor microenvironment following vaccination
Dalton Hermans, Sloane Christian Fussell, Andrei Ramirez-Valdez, Sam Shepard, Remi Poulard, Sonia Zumalave, Benjamin Louis Sievers, Christopher M. Garliss, Vincent L. Coble, Geoffrey M. Lynn, Andrew S. Ishizuka, Isidro Cortés‐Ciriano, Robert A. Seder
This study shows that stem-like CD8+ T cells, when used in adoptive cell therapy followed by vaccination, improve tumor control by altering the tumor microenvironment's transcriptomic profile.
bioRxiv · May 14, 2026 · PreprintImmunology