Human memory CD4+ T cells recognize Mycobacterium tuberculosis-infected macrophages amid broader pathogen-specific responses
Volodymyr Stetsenko, Daniel P. Gail, Scott M. Reba, Vinicius G. Suzart, Avinaash K. Sandhu, Alessandro Sette, Mohammad Haj Dezfulian, Cecilia S. Lindestam Arlehamn, Stephen M. Carpenter
The paper shows that most Mtb-specific CD4+ T cells from LTBI individuals recognize infected macrophages, but some require exogenous antigen, and identifies effector functions associated with TB protection.
bioRxiv · Feb 23, 2025 · PreprintImmunology