Cecilia S. Lindestam Arlehamn

Rare Variable M. tuberculosis Antigens induce predominant Th17 responses in human infection

The paper identifies Rare Variable Mtb Antigens (RVMA) that induce Th17 responses in human TB infection, suggesting their potential as vaccine antigens to enhance Th17 immunity.

Minimal immune cell subset differences in a cohort of close contacts of tuberculosis index cases

This study examines immune cell differences in close contacts of TB patients based on QFT status, finding minimal differences among subgroups but clear immune changes in active TB patients.

Enrichment of a CD4-CD8- NK-like cytotoxic Vδ1/3 T cell subset in tuberculosis disease

This study identifies an enriched NK-like cytotoxic Vδ3 T cell subset in TB patients using single-cell RNA sequencing, showing persistent transcriptomic differences post-treatment.

A novel method for characterizing cell-cell interactions at single-cell resolution reveals unique signatures in blood T cell-monocyte complexes during infection

The paper introduces a method to study cell-cell interactions at single-cell resolution, revealing unique transcriptomic signatures in T cell-monocyte complexes during TB and dengue infection.

T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease

The paper examines T cell responses to PINK1 and α-synuclein in prodromal Parkinson's disease, finding elevated reactivity comparable to clinically diagnosed PD.

Differential memory enrichment of cytotoxic CD4 T cells in Parkinson's disease patients reactive to α-synuclein

The paper investigates T cell subsets in Parkinson's disease patients reactive to α-synuclein, finding reduced Granulysin+ CD4 cytotoxic TEM cells and altered CELSR2 expression.

Peptide Driven Identification of TCRs (PDI-TCR) reveals dynamics and phenotypes of CD4 T cells in tuberculosis

PDI-TCR identifies Mtb-specific TCRs and characterizes their phenotypes in TB patients and healthy individuals, revealing distinct dynamics of specific and unspecific T cell responses.

Human memory CD4+ T cells recognize Mycobacterium tuberculosis-infected macrophages amid broader pathogen-specific responses

The paper shows that most Mtb-specific CD4+ T cells from LTBI individuals recognize infected macrophages, but some require exogenous antigen, and identifies effector functions associated with TB protection.

PINK1 is a target of T cell responses in Parkinson's disease

The paper identifies PINK1 as an autoantigen targeted by T cells in Parkinson's disease, with reactivity predominantly observed in male patients.

Predicting Immunogenic CD4+ T Cell Epitopes in Bacteria Using Antigen and Peptide Features

This paper develops a machine learning model that integrates peptide and antigen features to predict immunogenic CD4+ T cell epitopes in bacteria, achieving high accuracy across multiple bacterial species.

DAFi: A Directed Recursive Filtering and Clustering Approach to Data-Driven Identification of Cell Populations from Polychromatic Flow Cytometry Data

DAFi identifies cell populations from flow cytometry data by combining recursive filtering and clustering with user-defined constraints, improving resolution of overlapping and rare populations.