Amotosalen is a bacterial multidrug efflux pump substrate potentially affecting its pathogen inactivation activity
A. B. Green, K. E. Zulauf, K. A. Truelson, L. Chiaraviglio, M. Cui, Z. Zhang, M. P. Ware, W. A. Flegel, R. L. Haspel, E. W. Yu, J. E. Kirby
The paper investigates whether amotosalen, a psoralen used in pathogen inactivation, is a substrate for bacterial multidrug efflux pumps, finding it is pumped out by RND systems in E. coli and Acinetobacter baumannii, potentially reducing its inactivation efficacy against multidrug-resistant pathogens.
bioRxiv · Mar 15, 2021 · PreprintMicrobiology