Author

E. W. Yu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C.-C. Su· 2 shared A. B. Green· 1 shared A. L. Crooks· 1 shared B. L. Bauer· 1 shared B. Zhou· 1 shared C. S. Detweiler· 1 shared C. T. Meyer· 1 shared D. J. Taylor· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

C.-C. Su

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Bacterial Efflux Pump Modulators Prevent Bacterial Growth in Macrophages and Under Broth Conditions that Mimic the Host Environment

S. C. Allgood, C.-C. Su, A. L. Crooks, C. T. Meyer, B. Zhou, M. D. Betterton, M. R. Barbachyn, E. W. Yu, C. S. Detweiler

This paper identifies and improves efflux pump modulators (EPMs) that inhibit bacterial growth in macrophages and enhance antibiotic potency under host-like conditions.

bioRxiv · Sep 20, 2023Microbiology

Structural Basis for Regulated Assembly of the Mitochondrial Fission GTPase Drp1

K. Rochon, B. L. Bauer, N. A. Roethler, Y. Buckley, C.-C. Su, W. Huang, R. Ramachandran, M. S. K. Stoll, E. W. Yu, D. J. Taylor, J. A. Mears

This paper presents a cryo-EM structure of Drp1 dimer revealing conformational rearrangements that regulate its self-assembly and mitochondrial fission.

bioRxiv · Jun 22, 2023Cell Biology

Amotosalen is a bacterial multidrug efflux pump substrate potentially affecting its pathogen inactivation activity

A. B. Green, K. E. Zulauf, K. A. Truelson, L. Chiaraviglio, M. Cui, Z. Zhang, M. P. Ware, W. A. Flegel, R. L. Haspel, E. W. Yu, J. E. Kirby

The paper investigates whether amotosalen, a psoralen used in pathogen inactivation, is a substrate for bacterial multidrug efflux pumps, finding it is pumped out by RND systems in E. coli and Acinetobacter baumannii, potentially reducing its inactivation efficacy against multidrug-resistant pathogens.

bioRxiv · Mar 15, 2021 · PreprintMicrobiology