Author

W. C. H. Cross

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

A. Sottoriva· 3 shared T. A. Graham· 3 shared A.-M. Baker· 2 shared B. Werner· 2 shared E. Lakatos· 2 shared M. Jansen· 2 shared M. Robertson-Tessi· 2 shared M. Rodriguez-Justo· 2 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCancer Biology

A. Sottoriva

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMar 6, 2022

Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer

H. Kayhanian, P. Barmpoutis, E. Lakatos…·M. Jansen

The paper shows that mutation rate adaptation in MMRd cancers drives immune escape by modulating neoantigen diversity and subclonal mutation rates.

DOI 10.1101/2022.03.06.482973

humanwhole-genome sequencing

𝕏 PostBluesky

Cancer BiologyNature GeneticsPeer-reviewedSep 14, 2020

Evolutionary dynamics of neoantigens in growing tumours

E. Lakatos, M. J. Williams, R. O. Schenck…·T. A. Graham

This study develops a mathematical model of neoantigen evolution in tumors and validates it with colorectal cancer data, showing how negative selection shapes tumor immunogenotype and clonality.

DOI 10.1038/s41588-020-0687-1

humanwhole-exome sequencing

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMay 3, 2019

Niche engineering drives early passage through an immune bottleneck in progression to colorectal cancer

C. D. Gatenbee, A.-M. Baker, R. O. Schenck…·A. Anderson

The paper models tumor-immune dynamics in colorectal cancer progression, showing immune evasion enables transition from immune-hot adenomas to immune-cold carcinomas.

DOI 10.1101/623959

humanbulk RNA-seq

𝕏 PostBluesky