MDA5 is an essential vita-PAMP sensor necessary for host resistance against Aspergillus fumigatus
X. Wang, A. K. Caffrey-Carr, K.-w. Liu, V. Espinosa, W. Croteau, S. Dhingra, A. Rivera, R. A. Cramer, J. J. Obar
This study shows MDA5 is essential for host resistance against Aspergillus fumigatus through type I and III interferon signaling and antifungal neutrophil activity.
bioRxiv · Jul 6, 2020Immunology