Author

J. J. Obar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

R. A. Cramer· 4 shared K.-W. Liu· 3 shared X. Wang· 3 shared A. K. Caffrey-Carr· 2 shared B. S. Ross· 2 shared C. H. Kowalski· 2 shared J. E. Stajich· 2 shared J. T. Jones· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersImmunology

R. A. Cramer

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4 papers

Recent·Most cited

Post-Influenza Environment Reduces Aspergillus fumigatus Conidia Clearance and Facilitates Invasive Aspergillosis In Vivo

K.-W. Liu, M. S. Grau, J. T. Jones, X. Wang, E. M. Vesely, M. R. James, C. Gutierrez-Perez, R. A. Cramer, J. J. Obar

This study shows that influenza virus infection impairs neutrophil and monocyte function, reducing Aspergillus fumigatus conidia clearance and increasing invasive aspergillosis in mice.

bioRxiv · Oct 14, 2022 · PreprintImmunology

Host lung environment limits Aspergillus fumigatus germination through a SskA-dependent signaling response

M. E. Kirkland, M. Stannard, C. H. Kowalski, D. L. Mould, A. K. Caffrey-Carr, R. M. Temple, B. S. Ross, L. A. Lofgren, J. E. Stajich, R. A. Cramer, J. J. Obar

The paper identifies a SskA-dependent signaling pathway that limits Aspergillus fumigatus germination in the host lung environment, enhancing disease initiation and inflammation.

bioRxiv · Aug 27, 2021Microbiology

Strain specific persistence in the murine lung of Aspergillus fumigatus conidia causes an Allergic Broncho-Pulmonary Aspergillosis-like disease phenotype

J. T. Jones, K.-W. Liu, X. Wang, C. H. Kowalski, B. S. Ross, K. A. M. Mills, J. D. Kerkaert, T. M. Hohl, L. A. Lofgren, J. E. Stajich, J. J. Obar, R. A. Cramer

This study identifies an A. fumigatus strain, W72310, that persists in the mouse lung and causes ABPA-like disease without significant hyphal growth.

bioRxiv · Dec 4, 2020Microbiology

MDA5 is an essential vita-PAMP sensor necessary for host resistance against Aspergillus fumigatus

X. Wang, A. K. Caffrey-Carr, K.-w. Liu, V. Espinosa, W. Croteau, S. Dhingra, A. Rivera, R. A. Cramer, J. J. Obar

This study shows MDA5 is essential for host resistance against Aspergillus fumigatus through type I and III interferon signaling and antifungal neutrophil activity.

bioRxiv · Jul 6, 2020Immunology