Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice
A. Wells, K. Grimes, K. Kim, E. Branche, C. Bakkenist, W. DePas, S. Shresta, C. Coyne
This study shows that hFcRn and IFN signaling determine echovirus pathogenesis in mice, with hFcRn-IFNAR-/- mice modeling human disease.
bioRxiv · Sep 24, 2020Microbiology