Author

S. Shresta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:protein structure prediction· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Organism:plant (other)· 1

Frequent Co-Authors

E. Olmedillas· 2 shared A. Baehr· 1 shared A. Moretti· 1 shared A. Wells· 1 shared B. Shashikadze· 1 shared C. Bakkenist· 1 shared C. Baumgartner· 1 shared C. Coyne· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

E. Olmedillas

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation

E. Olmedillas, R. R. Rajamanickam, R. Diaz, F. A. Sosa Batiz, M. A. Zandonatti, S. S. Harkins, S. Shresta, K. Hastie, E. O. Saphire

This study presents a pre-fusion, open conformation of the SARS-CoV-2 S2 subunit and identifies antibodies that recognize it, providing insights into spike dynamics and potential vaccine targets.

bioRxiv · Dec 14, 2023Microbiology

Gene Therapy for Cardiomyopathy associated with Duchenne Muscular Dystrophy in a Pig Model

A. Baehr, P. Hoppmann, T. Bozoglu, M. Stirm, I. Luksch, T. Ziegler, N. Hornaschewitz, S. Shresta, B. Shashikadze, J. B. Stöckl, N. Raad, H. Blum, S. Krebs, T. Fröhlich, C. Baumgartner, , C. Kupatt

This study shows that AAV1.SERCA2a gene therapy improves heart function and reduces arrhythmia in a pig model of Duchenne muscular dystrophy.

bioRxiv · Oct 2, 2023 · PreprintPhysiology

Structure-based design of a highly stable, covalently-linked SARS-CoV-2 spike trimer with improved structural properties and immunogenicity

E. Olmedillas, C. J. Mann, W. Peng, Y.-T. Wang, R. Diaz Avalos, D. Bedinger, K. Valentine, N. Shafee, S. L. Schendel, M. Yuan, G. Lang, R. Rouet, D. Christ, W. Jiang, I. A. Wilson, , E. Ollmann Saphire

This paper designs a modified SARS-CoV-2 spike trimer, VFLIP, with enhanced stability, immunogenicity, and structural fidelity to the native spike.

bioRxiv · May 6, 2021 · PreprintMicrobiology

Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice

A. Wells, K. Grimes, K. Kim, E. Branche, C. Bakkenist, W. DePas, S. Shresta, C. Coyne

This study shows that hFcRn and IFN signaling determine echovirus pathogenesis in mice, with hFcRn-IFNAR-/- mice modeling human disease.

bioRxiv · Sep 24, 2020Microbiology