W. Dun

Extracellular Matrix Instability and Chronic Inflammation Underlie Maladaptive Right Ventricular Pressure Overload Remodeling and Failure in Male Mice

This study shows male mice with pulmonary artery banding develop severe right ventricular dysfunction and failure due to ECM instability and chronic inflammation, while females show more adaptive remodeling without these features.

Increased spontaneous Ca2+ activity in Cardiac Purkinje cells after myocardial infarction; A consequence of a dramatic shift of SERCA isoforms as potential adaptation to acute ischemia?

This study shows that increased spontaneous Ca2+ activity in cardiac Purkinje cells after myocardial infarction is due to a shift in SERCA2 isoforms, specifically increased SERCA2b and reduced SERCA2a.